• The orientation of the immobilized enzyme may affect its act

  2022-06-06

  

  The orientation of the immobilized enzyme may affect its activity and stability and therefore the final biocatalyst performance. Since proteins present areas more prone to unfolding in their surface or near to it [36], the immobilization through these areas may improve the final biocatalyst stabilit

• All of the abovementioned effects of PUFAs signal

  2022-06-06

  

  All of the abovementioned effects of PUFAs signal their involvement in a cellular phenotype switching phenomenon, which is increasingly recognized as a potential target for future pharmacotherapies of atherosclerosis, especially for individuals who do not respond to the classical lipid-lowering stra

• br Introduction A great many

  2022-06-06

  

  Introduction A great many isoprenoids with varieties of structural diversity, such as steroids, carotenoids, prenyl quinones, and natural rubber, occur in nature. All of these biosynthetic precursors are constructed by the action of prenyl chain elongating enzymes [1], [2], [3], [4]. These enzyme

• Over the last decade intense efforts have been devoted

  2022-06-06

  

  Over the last decade, intense efforts have been devoted toward identifying IN inhibitors as potential drugs against HIV. Raltegravir and elvitegravir are integrase strand transfer inhibitors (INSTIs) that have been approved for therapy and dolutegravir is another INSTI that is currently in advanced

• H R antagonism can prevent seizure development and improve w

  2022-06-06

  

  H3R antagonism can prevent seizure development and improve working memory through the activation of histaminergic neurons (Huang et al., 2004, Zhang et al., 2003). In addition, we have recently found that H3R antagonism protects against ischemia-reperfusion injury via histamine-independent mechanism

• br Materials and methods br Results br

  2022-06-06

  

  Materials and methods Results Discussion The major findings of the present study are that: 1) the response to inverse agonists may be crossregulated by the activation of either LY2940680 H1 or H2 receptors, 2) histamine H1 and H2 receptor inverse agonists crossdesensitize the receptor´s re

• br STAR Methods br Acknowledgments We thank the TCGA PanCanA

  2022-06-06

  

  STAR★Methods Acknowledgments We thank the TCGA PanCanAtlas Analysis Working Group. This study was supported in part by grants from the NIH (CA175486 and CA209851 to H.L., CA217842 to G.B.M., and CCSG grant CA016672); a grant from the Cancer Prevention and Research Institute of Texas (RP140462

• Recently CFS has been included in

  2022-06-05

  

  Recently, CFS has been included in the group “low cystine and glutamine syndromes,” which are characterized by a combination of abnormally low plasma levels of these two aminoacids, as well as reduced natural killer cell activity, and increased rates of urea production [13]. Some studies indicated

• Alzheimer s disease AD is

  2022-06-05

  

  Alzheimer's disease (AD) is a neurodegenerative disorder and characterized by the presence of abnormal filamentous protein inclusions in nerve cells of the brain [2]. The neuropathological hallmarks of AD were first reported by Alois Alzheimer and date back to 1907 [3], [4]. These inclusions are for

• The compounds described in this paper were prepared using

  2022-06-05

  

  The compounds described in this paper were prepared using a modular approach that allowed diversification of R or R at the final step (). Route A involved amide coupling of -butyl 4-(methylamino)piperidine-1-carboxylate with phenyl acetic acids (step a) using 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-m

• Niacin nicotinic acid is widely used to regulate abnormaliti

  2022-06-05

  

  Niacin (nicotinic acid) is widely used to regulate abnormalities in plasma lipid and lipoprotein metabolism, as evidenced by its potential for reducing atherosclerotic cardiovascular disease risks (Guyton, 1998), due to its ability to reduce circulating triglycerides and apolipoprotein-B containing

• For a long time the mechanism for the TG

  2022-06-05

  

  For a long time, the mechanism for the TG-lowering effect of nicotinic THZ531 has been thought that the lowered NEFA substrate from adipose tissue limits TG production from the liver (so-called NEFA hypothesis) [[1], [2], [3], [4]]. However, recent emerging evidences have suggested the involvement o

• Maprotiline HCl br Material and methods br Results

  2022-06-05

  

  Material and methods Results Consistent with our previous study, SR-SIM and confocal microscopy showed a large number of IBA1-expressing Maprotiline HCl in all parts of the human cochleae (Fig. 1). IBA1, the microglial and macrophage-specific calcium-binding protein, is involved in the membra

• shows the hormonal and follicular

  2022-06-05

  

  shows the hormonal and follicular growth profile of the woman who ovulated in both cycles. In cycle 1, an LH surge occurred on day 17, when serum oestradiol concentration was 210.5 pg/ml and follicle diameter 17 mm. In cycle 2, ganirelix administration was continued until day 19 instead of until the

• Obestatin synthetized mainly in the gastrointestinal tract p

  2022-06-05

  

  Obestatin, synthetized mainly in the gastrointestinal tract, participates in the regulation of metabolic functioning at both central and peripheral levels (food intake, pancreatic activity or/and adipocytes proliferation) (Granata et al., 2008; Li et al., 2011). It is involved in the complex gut-bra

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